Irradiation is a phytosanitary treatment used in the international trade of fresh fruits and vegetables. It slows down the ripening process by delaying respiration rate and ethylene production in different fruits. Mango (Mangifera indica L.) is a climacteric and perishable fruit that requires sophisticated postharvest treatment to increase its shelf life and allow it to be sent internationally. The study was carried out on a commercial-scale experiment to see how modified atmosphere packaging (MAP) affected the shelf-life of irradiation 'Nam Doc Mai Si Thong' mango. After the postharvest process was completed, we placed four packages of white ethylene-absorbing bags (WEB1 and WEB2) and polypropylene (MAP1 and MAP2) into each corrugated box, which differed in attributes such as oxygen transmission rate (OTR).The mangoes were then exposed to 400 Gray x-ray or gamma radiations. The irradiated-MAP storage investigations were carried out in a 40-foot refrigerated container at 13–15 °C for 15 days, then at ambient temperature (25–27 °C). At both storage conditions, the respiration rate of mangoes in WEB1 and WEB2 packages with OTR less than 10,000 cc/m2/24 h slowly increased. During the storage time in ambient, the ethylene production in WEB1 and WEB2 packages remained steady. After being refrigerated at 13–15 °C, these WEB considerably reduced the disease incidence rate of mangoes. The ripening process was effectively slowed, and the physicochemical properties of the mangoes were retained for up to 24 days, compared to 15 days shelf-stable in the non-MAP package. When x-rays were used, similar findings were observed. To lengthen the shelf life of the 'Nam Doc Mai Si Thong' mango, irradiation and proper modified atmosphere packaging can be coupled.