Posters - Networking - Exhibition

Wednesday November 09, 2022 from 13:30 to 17:00

Room:

POS-22 Comparison of X-rays and gamma-rays irradiation of polymer: An EPR study

Nicolas Ludwig, France

Reasearch Scientist
Irradiation/Dosimetry
Aerial

Abstract

Comparison of X-rays and gamma-rays irradiation of polymer: An EPR study

Nicolas Ludwig1, Florent Kuntz1, Samuel Dorey2, Nina Girard-Perier2, Sylvain R A Marque3, Nathalie Dupuy4.

1Aerial CRT, Illkirch, France; 2Sartorius Stedim FMT S.A.S, Aubagne, France; 3ICR, Aix Marseille University, Marseille, France; 4IMBE, Aix Marseille University, Marseille, France

In an effort to fill data, knowledge and tool gaps that could reduce the expansion of X-ray for sterilization purpose, a comparative work has been realized on radio-induced free radicals in plastics after X-rays and gamma-rays from 60Co treatment. Radicals generated in polymers are the seeds for short and long-term modifications. Identifying and quantifying them can help evaluating interaction similarities between the two irradiation modalities.

The study presented hereafter has evaluated ~50 grades of polymers from most classical families found in medical and biopharmaceutical applications.  The polymer grades have been selected from Sartorius typical components.

 

Irradiations have been conducted at Aerial feerix® 7 MV X-rays irradiation plant (Illkirch-France) and at Ionisos Dagneux-France facility with 60Co gamma-rays. A unique dose of 50 kGy +/- 10% has been applied for both irradiation modalities.

Measurements have been conducted over one year period of aging with the following occurrence: Day 1, Week 1 and 2, Month 1, 2, 3 and 6 and Year 1. Between measurements, sample were aged in the dark in a controlled environment (22°C +/- 2°C and 45% +/- 15% RH).

 

In a qualitative point of view, each material exhibits similar EPR spectra when irradiated with X-rays or gamma-rays. This suggests that same radicals are measured and thus, occurring radiation induced mechanisms are very comparable.

In a quantitative point of view, large majority of the ~50 materials did not show a significant radical concentration difference produced when irradiated with gamma-rays or X-rays. The general trends which could be established on radical generation between X-rays and gamma-rays will be further discussed.


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